Dexamethasone for PONV after laparoscopic cholecystectomy

Congratulations to MRGE members (Kamal Awad and colleagues) for their recent publication in the International Journal of Surgery “Dexamethasone combined with other antiemetics versus single antiemetics for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: An updated systematic review and meta-analysis”.

Dexamethasone is a steroid, showed to have a potent antiemetic activity. However, PONV are multifactorial in origin and none of the available antiemetics, including dexamethasone, is solely effective to prevent them. Therefore, several studies added other antiemetics to dexamethasone to improve the antiemetic effect by acting on different receptors. A systematic review and meta-analysis of published randomized controlled trials was performed to update the present evidence about the safety and efficacy of dexamethasone combined with other antiemetics versus single antiemetics for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.

This paper has been published in “International Journal of Surgery” with IF=1.53 and one of the world leading journals in surgery.

HIGHLIGHTS

  • We conducted a meta-analysis to compare the safety and efficacy of dexamethasone combined with other antiemetics versus single antiemetics for the prevention of PONV after LC.
  • Only well-designed RCTs were included and we excluded trials of questioned validity, performed by the author Yoshitaka Fujii.
  • The combination of dexamethasone with another antiemetic has more efficacy than single antiemetics in preventing PONV after LC.

URL: http://www.sciencedirect.com/science/article/pii/S1743919116309918

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